Marc Carnicer CV

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Dr. Marc Carnicer

Assistant Professor 
Bioengineering Department, IQS.
marc.carnicer@iqs.url.edu
Bioprocess development.

CURRICULUM VITAE (2021)

Marc Carnicer Heras, Laboratory of Biochemistry
Bioengineering Department, Institut Químic de Sarrià (IQS), Universitat Ramon Llull
Via Augusta 390, 08017 Barcelona, Spain
Tel: +34-932672000, e-mail: marc.carnicer@iqs.url.edu

A. Education

Universitat de Barcelona (UB) Biochemistry B.S. 2007
Uni. Autònoma de Barcelona (UAB) Advanced Biotechnology MSc 2008
Uni. Autònoma de Barcelona (UAB) Biotechnology Ph.D. 2012

B. Positions and Honors
(i) Positions and Employment

2019 – present Project Manager at Bioprocess Pilot Plant at IQS
2015 – present Assistant professor, Institut Químic de Sarrià, Universitat Ramon Llull
2014 – 2015 Specialist Researcher, INSA de Toulouse
2012 – 2014 Postdoctoral Researcher, INSA de Toulouse
2012 – 2012 Specialist Researcher, Universitat Autònoma de Barcelona

(ii) Honors

2012 PhD Extraordinary Award, Universitat Autònoma de Barcelona

C. Contribution to Science (full list of articles at Google Scholar Citations)

(i) Graduate Career: My graduate research framed inside the GENOPHYS European project (BIO2005-23733-E) aimed the Genome-Wide Comparison of Physiological Bottlenecks in Multi-Subunit Protein Production in Prokaryotic and Eukaryotic Microbial Hosts. My contributions were focused on understanding the metabolism of Pichia pastoris, a well-recognized system for recombinant protein expression, under different oxygen conditions. My studies were highly relevant as they provided new insight in the metabolome and the fluxome of this strain producing an antibody fragment as recombinant protein model. 

  1. Carnicer M, Baumann K, Töplitz I, Sánchez-Ferrando F, Mattanovich D, Ferrer P, et al. Macromolecular and elemental composition analysis and extracellular metabolite balances of Pichia pastoris growing at different oxygen levels. Microb Cell Fact. 2009;8:65–78
  2. Baumann K, Carnicer M, Dragosits M, Graf AB, Stadlmann J, Jouhten P, et al. A multi-level study of recombinant Pichia pastoris in different oxygen conditions. BMC Syst Biol. BioMed Central Ltd; 2010;4:141.
  3. Carnicer M, Canelas AB, Pierick A, Zeng Z, Dam J, Albiol J, et al. Development of quantitative metabolomics for Pichia pastoris. Metabolomics. 2012;8:284–98.
  4. Carnicer M, Ten Pierick A, van Dam J, Heijnen JJ, Albiol J, van Gulik W, et al. Quantitative metabolomics analysis of amino acid metabolism in recombinant Pichia pastoris under different oxygen availability conditions. Microb Cell Fact. Microbial Cell Factories; 2012;11:83.

(ii) Postdoctoral Career: As a postdoctoral fellow, my research was framed inside the PROMYSE European project (FP7- KBBE-2011-3-6-04) aimed at producing different kinds of bio-based products out of methanol. My work was to further understand the methanol assimilation capacities of the gram-positive strain Bacillus methanolicus and transfer these features to non-native methylotrophs such as Escherichia coli, Bacillus subtilis and Corynebacterium glutamicum.

  1. Carnicer M, Vieira G, Brautaset T, Portais J-C, Heux S. Quantitative metabolomics of the thermophilic methylotroph Bacillus methanolicus. Microb Cell Fact. BioMed Central; 2016;15:92.
  2. Vieira G, Carnicer M, Portais J-C, Heux. S. FindPath: A Matlab solution for in silico design of synthetic metabolic pathways. Bioinformatics. 2014;30:2986–8.
  3. Delépine B, López MG, Carnicer M, Vicente C, Wendisch V, Heux S. Charting the metabolic landscape of the facultative methylotroph Bacillus methanolicus. mSystems. 2020;5:e00745-20.

(iii) Assistant professor Career: As assistant professor I started a new research line in 2018 focused on developing new sustainable production processes based on a non-food material, acetic acid. In my previous research, methanol was selected as alternative feedstock but many limitations appeared such as limited host availability, highly constrained metabolism, high oxygen demands or toxicity at rather low concentration. Acetate, in contrast, can be assimilated for a great variety of cells, including the most common industrial hosts, and its metabolisms is much less constrained compared to methanol. These facts, together with its lower price ($350 – 400 per ton) compared to glucose ($500 per ton), has converted it into a great candidate for biotechnological transformation in to value-added products from renewable sources. 

(iv) PhD thesis advisor and other graduate student programs

  1. 1 PhD Thesis on going.
  2. 12 Master Thesis (2015-2020).
  3. Jury member of PhD dissertations: 4.

(v) Scientific index. Source: WOS at 18/02/2021 

  1. H-index: 10
  2. Total Publications: 12
  3. Average citations per publication: 37.2

D. Teaching Experience

2018 – present Synthetic Biology Master Bioengineering (IQS)
2016 – present Gene to product Laboratory Master Bioengineering (IQS)
2016 – present Bioprocess Design and simulation Master Bioengineering (IQS)
2016 – present Downstream Processing Master Bioengineering (IQS)
2015 – present Downstream Processing Biotechnology Degree (IQS)
2015 – present Upstream Processing Laboratory Biotechnology Degree (IQS)
2015 – present Genomic, Proteomic and Metabolomic Biotechnology Degree (IQS)
2011 – 2012 Downstream Processing Biotechnology Degree (UAB)
2011 – 2012 Integrated Laboratory Biotechnology Degree (UAB) 
2011 – 2012 Biochemical engineering Chemical Eng. Degree (UAB)

E. Others

  1. Participation in 4 National Projects (MINECO, Spain). The last one accepted for 2020-2022 (PID2019-104350RB-I00).
  2. Participation in international Congresses: 9.
  3. Coordinator of the PROMYSE final Meeting. Barcelona 2014.
  4. Lector accreditation 2017
  5. Accredited Research Experience: 1 Sexenni (2008 – 2014)